Ultrafast Fluorescence Relaxation Spectroscopy of 6,7-Dimethyl-(8-ribityl)-lumazine and Riboflavin, Free and Bound to Antenna Proteins from Bioluminescent Bacteria
نویسندگان
چکیده
Valentin N. Petushkov,†,‡ Ivo H. M. van Stokkum,§ Bas Gobets,§ Frank van Mourik,§,# John Lee,⊥ Rienk van Grondelle,§ and Antonie J. W. G. Visser*,†,∇ MicroSpectroscopy Centre, Laboratory of Biochemistry, Wageningen UniVersity, Dreijenlaan 3, 6703 HA Wageningen, The Netherlands, Department of Physics and Astronomy, Faculty of Sciences, Vrije UniVersiteit, De Boelelaan 1081, 1081 HV Amsterdam, The Netherlands, Department of Biochemistry and Molecular Biology, UniVersity of Georgia, Athens, Georgia 30602, and Department of Structural Biology, Faculty of Earth and Life Sciences, Vrije UniVersiteit, De Boelelaan 1087, 1081 HV Amsterdam, The Netherlands
منابع مشابه
Isolation of 4-( l’-~-Ribitylamino)-5-amino-2,6-l dihydroxypyrimidine from a Riboflavin-Adenine-deficient Mutant of BaciZZus subtiZis*
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متن کاملDesign, synthesis, and biochemical evaluation of 1,5,6,7-tetrahydro-6,7-dioxo-9-D-ribitylaminolumazines bearing alkyl phosphate substituents as inhibitors of lumazine synthase and riboflavin synthase.
The last two steps in the biosynthesis of riboflavin, an essential metabolite that is involved in electron transport, are catalyzed by lumazine synthase and riboflavin synthase. To obtain structural probes and inhibitors of these two enzymes, two ribityllumazinediones bearing alkyl phosphate substituents were synthesized. The synthesis involved the generation of the ribityl side chain, the phos...
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تاریخ انتشار 2003